A large fire that started earlier this afternoon in Eaglescliffe broke out at Melbray Chemicals, based at Chemical House on Wass Way, on the Durham Lane Industrial Estate.
Cleveland Police say the smoke is not believed to be toxic.
The business was set up in 1988 and is described as a manufacturer of organic base chemicals.
A sign on the company’s headquarters says the business is involved in “oilfield, chemical, additives and technology”.
The Gazette has been unable to reach the firm for comment.
For live updates on the fire follow The Gazette's blog here.
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